Synergic antibacterial effect between Maillard reactive product (MRP) and hydrogen peroxide (H2O2) on Streptococcus mutans

Objectives: To evaluate the antibacterial activity of resin composite containing Maillard reactive product (MRP) and hydrogen peroxide (H 2 O 2 ) on Streptococcus mutans ( S. mutans ), and to investigate the antibacterial mechanism involved. Methods: The growth of S. mutans was investigated after dental resin containing H 2 O 2 in the presence and absence of MRP, was immersed into bacterial solution. The effect of MRP on H 2 O 2 degradation was examined by the measurement of H 2 O 2 content. Results: The resin composite containing MRP and H 2 O 2 showed stable antibacterial activity compared with resin containing H 2 O 2 only, and the effect of MRP was speculated to be the suppression of H 2 O 2 degradation, and the presence of H 2 O 2 correlated with the antibacterial activity of resin composite. These results indicated that the antibacterial activity of resin composite containing MRP and H 2 O 2 on S. mutans was dependent on the presence of H 2 O 2 , and MRP suppressed the degradation of H 2 O 2 after combination with H 2 O 2 . EDTA also suppressed the degradation of H 2 O 2 . Conclusions: An antibacterial effect of resin composite containing MRP and H 2 O 2 on S. mutans was observed. The effect of MRP on H 2 O 2 might be a metal chelating action. Application of resin composite containing MRP and H 2 O 2 to a caries dentine could be an alternative therapy to or serve as an additional minimally invasive antibacterial treatment.