In vitro and In vivo Assessment of Suitable Reference Region and Kinetic Modelling for the mGluR1 Radioligand [11C]ITDM in Mice

Daniele Bertoglio,Jeroen Verhaeghe,Špela Korat,Alan Miranda,Leonie wyffels,Sigrid Stroobants,Ladislav Mrzljak,Celia Dominguez,Longbin Liu,Mette Skinbjerg,Ignacio Munoz-Sanjuan,Steven Staelens

In vitro and In vivo Assessment of Suitable Reference Region and Kinetic Modelling for the mGluR1 Radioligand [11C]ITDM in Mice

2019

Daniele Bertoglio
Jeroen Verhaeghe
Špela Korat
Alan Miranda
Leonie wyffels
Sigrid Stroobants
Ladislav Mrzljak
Celia Dominguez
Longbin Liu
Mette Skinbjerg
Ignacio Munoz-Sanjuan
Steven Staelens

Purpose This study aimed at investigating binding specificity, suitability of reference region-based kinetic modelling, and pharmacokinetics of the metabotropic glutamate receptor 1 (mGluR1) radioligand [11C]ITDM in mice.

Keywords:

Reference Region
Nuclear medicine
In vitro
Radioligand
Medicine
Pharmacology
Metabotropic glutamate receptor 1
Preclinical imaging
Binding selectivity
In vivo
Pharmacokinetics
Positron emission tomography
Volume of distribution
Biomedical engineering
Population

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations