Effects of hyperbaric oxygen on skin ischemia induced by hyaluronic acid

Objective To observe the therapeutic effects of hyperbaric oxygen (HBO) on skin ischemia induced by hyaluronic acid. Methods Forty-two patients with skin ischemia induced by hyaluronic acid were divided into 2 groups: The patients in group A were given routine treatment, and some patients received HBO therapy 72 hours later, while the patients in group B all received HBO therapy within 72 hours after injection of hyaluronic acid on the basis of routine therapy. Effectual time was recorded and compared between the patients of the 2 groups, and Pearson analysis was performed with respect to HBO implementation time and effectual time. Effectual rates were compared between the 2 groups, 10 days after injection of hyaluronic acid. Results The average effectual time of group A was(13.2±2.8)days, while that of group B was(11.0±3.1)days. Statistical significance could be noted when comparisons were made between them (P 0). Observation at day 10 showed that the effectual time of group A was 28.57% and that of group B was 53.57%. Conclusion Therapeutic effects of early HBO therapy on skin ischemia induced by hyaluronic acid injection was positive, and the earlier HBO intervention was made, the earlier the effectual time was. Key words: Hyaluronic acid; Hyperbaric oxygen; Skin ischemia