259: Relationships between chronic use of statins, presentation of acute coronary syndrome and one-year mortality after a first event in patients from the French MONICA registries

Purpose Statins have demonstrated their efficacy in many situations to prevent cardiovascular risk. In this work we investigated the link between chronic use of statins, type of subsequent acute coronary syndrome (ACS), namely ST-elevation myocardial infarction (STEMI) or unstable angina/non ST-elevation myocardial infarction (UA/NSTEMI), early complications and their impact on one-year mortality in real life conditions. Methods Our study was based on 2006 data from the French MONICA population-based registry which collects all cases of ACS occurring in people aged 35-74 in 3 French areas. The sample consisted of 1951 hospitalized incident ACS (72 were excluded because of missing data). Relationship between chronic use of statins and type of ACS or early complications (resuscitated cardiac arrests and shocks) were analyzed through logistic regression. Impact on one-year mortality was evaluated through Cox models. Analyses were adjusted for patients’ characteristics (living area, age, gender and previous cardiovascular treatments). Results Before index event, the rate of statins treated patients was 18%. The percentage of UA/NSTEMI among all hospitalized ACS was 45%; 54.5% in patients with previous statins treatment and 42.9% in those without (p Conclusions In our registry, people already treated with statins before an incident ACS had a lower rate of one-year mortality. This may result from a lower probability to develop STEMI, or early complications. However it remains difficult to assess from these observational data what is related to the treatment and what is related to potential confounding bias.