Pharmacokinetic study of Meloxicam in poultry following multiple doses by intramuscular administration

The present study was undertaken to investigate the pharmacokinetics and tissue residue study of meloxicam at a dose rate of 0.5 mg/kg body weight in poultry (n=8) following multiple (5) doses intramuscular administration. The concentration of meloxicam in plasma and tissue of these animals were analysed by High-performance liquid chromatography (HPLC) with Ultra Violet (UV) detector. Following multiple doses i.m. administration volume of distribution, clearance, area under curve (AUC) and elimination half-life were estimated after first dose was 194.38 ml.kg-1, 57.19 ml.h-1.kg-1, 8.91 h.µg.ml-1 and 2.42h, respectively and 189.32 ml.kg-1, 67.56 ml.h-1.kg-1, 8.32 h.µg.ml-1 and 2.18h after the last dose. Residue of meloxicam was not found in kidney, liver and muscle up to 48 hour post administration of meloxicam.