Influence of carbon disulphide on metabolic processes in the aorta wall: Study of the rate of cholesterol synthesis and the rate of influx of 14C-cholesterol from serum into the aorta wall

In our former experiments it was indicated that in chronic intoxication with CS2 body metabolism of cholesterol in animals is significantly disordered. Consequently, the level of cholesterol in blood increases and is accompanied by a rise in content of cholesterol, mainly its esterified form in the aorta. The present study revealed increased by CS2 rate of cholesterol influx from serum into the aorta wall and only slightly enhanced synthesis of cholesterol in this tissue. These results suggest that in chronic poisoning with CS2, similarly to the experimental atherosclerosis, the majority of cholesterol in the aorta wall derives from plasma.