Abstract 19212: Quantitative Relationship of End-Tidal Carbon Dioxide With Ventilation Characteristics During CPR

Background: End Tidal CO2 (ETCO2) has been used as a surrogate for systemic blood flow during CPR. Resuscitation guidelines suggest the use of ETCO2 for assessing chest compression effectiveness. While previous studies have found a relationship between deeper chest compression depth and higher ETCO2, there is paucity of clinical research examining the effect of ventilation parameters on ETCO2 during CPR. Objective: To quantify the relationship of ETCO2 independently with respiratory rate (RR), minute ventilation (MV) and tidal volume (TV) during clinical CPR. Methods: We performed an observational study which captured time synchronized respiratory data from adult cardiac arrest events at 2 sites between 02/2015-04/2016 using a respiratory profile monitor (Philips Respironics NM3, Andover, MA). ETCO2, RR, MV and TV were averaged over each minute and analyzed using mixed effects regression modeling to account for patient as a cluster. Results: 11 subjects had a total of 129 average breaths per min of respir...