TOXICITY OF POLYTRIN-C ON THE PSYCHOPHARMACOLOGICAL OBSERVATIONS IN WISTAR RAT.

The work has been designed to asses the neuro toxi city of a combination pesticide through behavioral parameters [Psychopharmacological observation] and instrumental analysis such as spontaneou s motor activity for 28 days. The mixed formulation s elected for the study, polytrin-C was used for sub acute and acute toxicity studies on Wister rats weighing around 90-120 gms of either sex.. Acute studies were carried out to fix the LD 50 dosage of the selected pesticide. Based on the LD 50 values the sub acute doses were fixed [1/40 th , 1/20 th , 1/10 th of the LD 50 Dosage]. It is evident from the resul ts that 1/20 and 1/10 of LD 50 dosed animals of either sex showed marked differ ences in the behavioral patterns when compare to 1/ 40 of LD 50 dose animals. Due to the synergetic effect neurotoxicity symptoms of combination pesticide results show a different toxicological profile when compare with the toxicity of constituent pesticide.