Concentrations of Prostaglandin E2 and Bradykinin in Cerebrospinal Fluid of Patients with Lumbar Disc Herniation

We investigated the concentrations of prostaglandin E2 (PGE2) and bradykinin (BK) in the cerebrospinal fluid of patients with lumbar disc herniation. The preoperative PGE2 and BK levels were 3.7±1.8pg/ml and 4.9±3.8pg/ml, respectively. The PGE2 and BK levels did not correlate with the severity of the leg pain. The postoperative PGE2 and BK levels were 4.5±2.9pg/ml and 5.6±2.9pg/ml, respectively. There were no differences between preoperative PGE2, BK levels and their postoperative levels. This result suggested that the PGE2 and BK concentrations in cerebrospinal fluid do not reflect the severity of the leg pain.