Induction of a chloracne phenotype in an epidermal equivalent model by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is dependent on aryl hydrocarbon receptor activation and is not reproduced by aryl hydrocarbon receptor knock down

A Forrester,Martina S. Elias,Emma L. Woodward,Mark A. Graham,Faith M. Williams,Nj Reynolds

Induction of a chloracne phenotype in an epidermal equivalent model by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is dependent on aryl hydrocarbon receptor activation and is not reproduced by aryl hydrocarbon receptor knock down

2014

A Forrester
Martina S. Elias
Emma L. Woodward
Mark A. Graham
Faith M. Williams
Nj Reynolds

Background 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a potent activator of the aryl hydrocarbon receptor (AhR) and causes chloracne in humans. The pathogenesis and role of AhR in chloracne remains incompletely understood.

Keywords:

Aryl hydrocarbon receptor
Keratinocyte
Enzyme inducer
Molecular biology
Chloracne
Pathogenesis
Activator (genetics)
Transfection
Biology
beta-Naphthoflavone

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