MRI of Pituitary Gland Morphology in Idiopathic Growth Hormone Deficiency in Stage of Adolescent and Its Correlation with Provocation Peaked of Growth Hormone

Objective To study diameter of adenohypophysis with isolated growth hormone deficiency(IGHD) in stage of adolescent and its correelation with provocation peaked of growth hormone(GH).Methods 52 cases of MRI data of adenohypophysis in IGHD adolescents range from7.2 year to 18.3 year were used,which were divided into 6-10 years old,10-15 years old,15.0-18.9 year group in adolescents.Using 1.5 T MR scanner,the appearances of adenohypophysis in 52 IGHD adolescents were analyzed on T1WI in sagittal and coronal plane,and to compare with normal control.Relation of the diamete of adenohypophysis in sagittal and coronal plane with GH provocation peak was analyzed.ResultsThe coronal and sagittal height diameter of adenohypophysis in 10-15 years old year group and 15-18.3 years old year group for male was grow down compare with normal control(P0.05).The coronal and sagittal height diameter and sagittal anteroposterior diameterof adenohypophysis in 10~15 years old year group for female was grow down compare with normal control(P0.05).The difference of diameter value of adenohypophysis with IGHD in different gender group and different age group was not statistically significant.The coronal and sagittal height diameter of adenohypophysis with IGHD was positive correlation with provocation peaked of GH(r=0.38,P0.01;r=0.32,P0.05).Conclusion The diameters of adenohypophysis with IGHD do not change following the gender and age.The height diameter of adenohypophysis with IGHD is positive correlation with provocation peaked of GH.