99. The Prevalence of Müllerian Anomalies in Females with a Diagnosed Renal Anomaly

Abstract Study Objective To characterize the prevalence of Mullerian anomalies (MA) among patients with renal anomalies (RA). Design, Setting, Participants, Interventions And Main Outcome Measures Retrospective chart review of female patients with RA presenting to an academic pediatric hospital between 2007 and 2019 was performed. Patients were identified using ICD-9 and ICD-10 codes. Data collected included the type of RA, presence and type of MA, method of diagnosis, and associated anomalies. RA subtype analysis was performed. Results 5590 cases of RA were identified between 2007 and 2019. A random, retrospective chart review was performed resulting in a study population of 363 RA patients. The prevalence of any MA in the overall RA population was 29% (95% CI = 24 – 33%). The prevalence of MA in patients with renal agenesis was 32% compared to 25% with renal dysgenesis. The most common MA were failures of Mullerian duct fusion. Only 21% of patients received screening for a MA at the time of RA diagnosis. 72% of patients without a diagnosed MA were unscreened and either not yet menarchal or had unknown menarchal status. Conclusions 29% of RA patients had an underlying MA. No difference was found in the prevalence of MA in patients with renal agenesis versus dysgenesis. Limitations noted are that some patients may be of an age where assessment of the Mullerian structures is suboptimal or who may not have been screened. These results suggest the need for a prospective study to determine evidence-based guidelines for screening for MA among patients diagnosed with any RA to avoid complications from an unrecognized MA.