Effect of intracellular diffusion on current--voltage curves in potassium channels
2014
We study the effect of intracellular ion diffusion on ionic currents
permeating through the cell membrane. Ion flux across the cell membrane
is mediated by specific channels, which
have been widely studied in recent years with
remarkable results: very precise measurements of the true current across
a single channel are now available. Nevertheless, a complete
understanding of this phenomenon is still lacking, though
molecular dynamics and kinetic models have provided partial insights. In
this paper we demonstrate, by analyzing the KcsA current-voltage
currents via a suitable lattice model, that intracellular diffusion plays
a crucial role in the permeation phenomenon. We believe that
the interplay between the channel
behavior and the ion diffusion in the cell
is a key ingredient
for a full explanation of the current-voltage curves.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
35
References
6
Citations
NaN
KQI