Radiation Therapy Using Synchrotron Radiation: Preclinical Studies Toward Clinical Trials

After decades of intensive research, high-grade gliomas are still resistant to therapies, including surgery, chemotherapy, and radiotherapy or a combination thereof. The most important advance in the treatment of these tumors has been the introduction of a new chemotherapy drug called temozolomide, in combination with external beam photon irradiation [1]. One of the goals of the association of the CHU/UJF/INSERM and ESRF teams has been to develop research on synchrotron radiotherapy up to clinics.