Correlation of Inflammation Mediator Profile Expression Between Tissues and Mucosal in Chronic Rhinosinusitis with Nasal Polyp

There are differences inflammatory patterns in Chronic Rhinosinusitis with Nasal Polyp (CRSwNP) between Caucasians and Asians. One of the most convenient and non-invasive examination tools to find out the inflammatory pattern of CRSwNP is such as mucosal brushing of the polyp. This research investigated the correlation of expression IL-5, IL-8, and IL-17A between the tissue and mucosal polyp.A cross-sectional comparative study involving 15 samples of mucosal brushing and 15 of polyp tissues were performed. We measured IL-5, IL-8, and IL-17A level of mucosal brushing with the Enzyme-Linked Immunosorbent Assay (ELISA) and polyp tissues with immunohistochemistry (IHC) examination. The mean expression of IL-5, IL-8, and IL-17A by IHC was 62.07% (26.294), 87.33% (16.969), 88.20% (16.781) and ELISA was 0.86 (0.13), 1930.60 (879.83), 25.60 (16.969). There was no significant relationship between tissue (IHC) and mucosa (ELISA) (p> 0.05), but in IL-5 expression there was a moderate positive correlation (0.41

Keywords:

• Mediator
• Immunology
• Medicine
• Inflammation
• chronic rhinosinusitis

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