Melatonin versus Gabapentin. A comparative study as preemptive medications

Postoperative pain is typically regarded as a type of nociceptive pain involving peripheral mechano-receptor stimulation. It is clear that inflammatory, neurogenic, and visceral mechanisms also contribute to acute pain symptoms. It has been suggested that central neuronal sensitization contributes to postoperative hypersensitivity to pain. As such, post-operative pain may be considered as a transient, reversible type of “neuropathic” pain and, consequently there is a rationale for the exploitation of anti-hyperalgesic drugs for post-operative analgesia.