170 The clinical and laboratory features of patients with systemic lupus erythematosus in kyrgyzstan

Background and aims There are no data regarding the real-life picture of SLE in Kyrgyzstan. Methods In a prospective observation included 325 patients with SLE, who were treated in NCCIM (2012 - 2016). Majority of these patients (301) were young women (median - 27 [25;41]), primarily Kyrgyz (284), with disease duration of 3 (median-3,0 [0.7;8.0]) years. Assessed SLEDAI 2K and SDI. Results They were mostly patients with acute variant of SLE-129 (39.7%), 127 (39.08%) were with high and 86 (26.46%) with very high activity. Most of the patients - 283 (87.1%) were registered with immunological activity. In most cases of the desease were: skin lesions (97.23%), serous membrane lesions (65.54%) and kidney lesions (59.38%). The neurological symptoms was noted in 120 patients (36.92%): 99 of 120 patients (82.5%) had a significant CNS lesions; 32 patients of 99 (32.3%) had neuropsychiatric disorders, 27 of these patients had visual and auditory hallucinatory syndrome. Respiratory disorders occurred in 60 (18.46%) patients. The vast majority of these patients were with pulmonary arterial hypertension (46.66%). Acute lupus pneumonitis was detected in 23 (38.33%) patients. At the onset of the study, SDI was identified in 65 patients (20%). These were mainly patients with irreversible changes in the kidney (30,8%), associated with taking GC (27.7%). Conclusions Acute onset of the disease (39.7%) was noted in most Kyrgyz patients. 97.23% of those ones with primary skin lesions, 65.54% with serous membrane lesions and 59.38% with kidney lesions, 39.92% patients had various neurological symptoms, 32.3% of these patients had serious neuropsychiatric disorders.