Neuroprotective Role of Curcumin in Alzheimer’s Disease

Curcumin, a vital ingredient of turmeric, has long been used in the treatment of a plethora of diseases, including neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. However, its therapeutic efficacy has been markedly impeded by its low solubility and poor bioavailability. To overcome these issues, potential drug-delivery systems (DDSs), using nanotechnology, were developed, which significantly enhance the therapeutic efficacy of curcumin. In contrast, a few DDSs failed to accomplish the target successfully. Therefore, this chapter highlights the therapeutic efficacy of curcumin and a number of DDSs used to encapsulate curcumin, and the challenges associated with DDSs, as well as casting light on future perspectives in this research area.