Prenylated sulfonyl amides from Glycosmis species.

Abstract Nine new sulfur containing amides were isolated from the lipophilic leaf extracts of different varieties of Glycosmis chlorosperma and G . ex aff. pseudoracemosa mainly collected in Thailand. Their structures were elucidated by spectroscopic methods. All amides were shown to be characterized by a methylsulfonylpropenoic acid moiety linked to a p -geranyloxy- or p -prenyloxy-phenethylamide rest. The compounds differ by different states of oxidation (i) at the 2-position of the ethylamine unit, (ii) at the aromatic m -position of phenethylamine, or (iii) at the terminal methyl group of the geranyloxy side chain.