Imidazotiadiazol derivatives as inhibitors of protease activated receptor 4 (Par4) for the treatment of platelet aggregation

A compound of Formula I: Formula ** ** or a stereoisomer, a tautomer, a pharmaceutically acceptable salt or solvate thereof, wherein: R10 is ** ** Formula wherein A, B and D are the same or different and are independently selected from N and C, with the proviso that a, B and D represent at least one carbon atom and at most 2 N atoms; X1 is selected from O, S or NR4; X2 is selected from CH, CR5 or N; R1 is selected from the group consisting of: halo, C1-C4 alkyl, C2-C3, C2-C3, C1-C4 alkoxy, C1-C4 alkylthio, phenylthio, C1-C4-NH, C1-C4 -O-C1-C4 alkyl, (C1-C4) 2 -N-, C3-C6 cycloalkyl, 4- to 10-membered, halo-C1-C2, containing 1 to 5 halogens, wherein halo is F or Cl, halo-C1-C2 alkoxy, containing 1 to 5 halogens, wherein halo is F or Cl, C1-C4 alkoxycarbonyl C1-C4 alkoxycarbonyl and C1-C4-alkoxy C1-C4 alkyl; R2 is selected from the group consisting of: H, halo, C1-C4 alkyl, C1-C4 alkoxy and cyano; Rx for each occurrence, is independently selected from the group consisting of: H, halo is F, Cl, Br or I, NR6R7, NO2, cyano, OH, C1-C4 alkoxy substituted with 0 to 3 groups Ra1 C1-C4 alkyl substituted with 0 to 3 groups Ra1, carboxy, carbonyl, C1-C4 substituted with 0 to 3 groups Ra1, alkylcarbonyl C1-C4 substituted with 0 to 3 groups R a1, C (> = O) NR6R7, alkylsulfonyl C1 C4 substituted with 0 to 3 groups R a1, S (> = O) 2NR6R7, C1-C4 alkyl substituted with 0 to 3 groups Ra1, fluoro-C1-C4 alkyl, containing from 1 to 5 fluorine or fluoro-alkoxy C1- C4, containing from 1 to 5 fluoro; or Rx is selected from YZ, where Z is a linker selected from the group consisting of: a single bond, -O-, -S -, ** ** Formula