Recurrent acoustic neurinoma after complete surgical resection

BACKGROUND: Mortality of acoustic neurinoma surgery is currently very low, well below the figures reported by the first surgeons. Morbidity has also declined with attempts at preserving the facial function and more recently hearing function. Long-term follow-up has demonstrated the well-known risk of recurrence after partial resection, but also evidenced a risk after complete resection. PATIENTS AND METHODS: We reviewed two series of patients, the first including 40 patients treated and followed at the Timone Hospital since 1975 and the second including 97 operated patients who were followed by the ENT Federation over 8 to 16 years. We studied recurrence after partial and complete resection. RESULTS: Recurrence rate was 20% after partial resection and 9.2% after complete resection. DISCUSSION: The 20% recurrence rate after partial resection was similar to that reported in the literature. After total extirpation, our 9.2% recurrence rate appears well above the 1% reported by others. Although our series could have a bias due to the large number of patients lost to follow-up, the large population size and the fact that we had a majority of large tumors would suggest that recurrence rate is generally underestimated. An 8 to 10% rate appears to be closer to reality. Most recurrences were late, with a peak around 8 years. We did however observe recurrences as early as 1 year and as late as 20 years. Delay appears to be shorter after partial removal. A wide range of localizations were observed but two areas predominated: the internal auditory canal and the components of the acousticofacial pedicle, and to a lesser degree the brain stem. Most patients were asymptomatic. The principal manifestations were balance disorders or trigeminal nerve lesions, more rarely facial palsy. But these clinical signs came late and generally signaled a bulky tumor measuring more than 3 cm. CONCLUSION: These findings lead us to insist on the need for radiological monitoring of all operated neurinomas irrespective of the initial surgery. MRI appears to be more accurate than computed tomography. Images must be interpreted carefully due to possible postoperative remodeling. For us, these observations point to the need for prolonged follow-up of at least 8 years, longer for young subjects, for all patients undergoing surgical resection of an acoustic neurinoma.