Urinary proteomic profiles of prostate cancer with different risk of progression and correlation with histopathological features.

Abstract Prostate cancer (PCa) is one of the most common tumor in men with extremely variable outcome, varying from latent or indolent form to very aggressive behavior. High grade tumors, expansions exceeding the prostatic capsule into the surrounding soft tissues and spreading through lymph vascular channels, represent the most consistent unfavorable prognostic factors. However, accuracy in the prediction of the disease progression is sometimes difficult. Along with new molecular diagnostic techniques and more accurate histopathological approaches, proteomic studies challenge to identify potential biomarkers predictive of PCa progression. In our study we analyzed the urinary proteomes of 42 patients affected by PCa through two-dimensional electrophoresis associated with mass spectrometry. Proteomic profiles were correlate to histopathological features including pTNM stage and tumor differentiation and lymphatic vascular invasion in order to provide new promising markers able to define more accurately the PCa aggressiveness and driving new therapeutic approaches.