Phase II study of cystemustine in metastatic colorectal carcinoma: A Trial of the EORTC Clinical Screening Group

Abstract 27 patients with metastatic colorectal carcinoma were treated, every 2 weeks, with 60 mg/m 2 cystemustine, a new chloro-2-ethyl nitrosourea derivative. Haematological toxicity was the major side-effect including neutropenia and thrombocytopenia. We did not observe any complete or partial response. Cystemustine, with this dose and this schedule, has no activity in colorectal cancer.