Abstract 11214: Ibrutinib Decreases Mitochondrial Oxidative Phosphorylation and Metabolic Gene Expression in Atrial-Like Engineered Heart Tissue

Julie H. Rennison,Beth Lovano,Laurie Castel,Cheryl R Lin,Feixong Cheng,Rohit Moudgil,Jonathan D. Smith,John Barnard,Mina K. Chung,David R. Van Wagoner

Abstract 11214: Ibrutinib Decreases Mitochondrial Oxidative Phosphorylation and Metabolic Gene Expression in Atrial-Like Engineered Heart Tissue

2021

Julie H. Rennison
Beth Lovano
Laurie Castel
Cheryl R Lin
Feixong Cheng
Rohit Moudgil
Jonathan D. Smith
John Barnard
Mina K. Chung
David R. Van Wagoner

Introduction: Ibrutinib is a Bruton kinase inhibitor which treats many hematological malignancies, but also precipitates atrial fibrillation (AF). The precise mechanism(s) remain to be elucidated. ...

Keywords:

Cancer research
Mechanism (biology)
Metabolism
Mitochondrion
Atrial fibrillation
Gene expression
Oxidative phosphorylation
Ibrutinib
Kinase
Medicine

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