Association of peripheral lymphadenopathy with anti-Ro and anti-La antibodies in a family with systemic lupus erythematosus.

We report here a mother and her two daughters suffering from systemic lupus erythematosus, accompanied by the presence of anti‐Ro (SSA‐52kD and 60kD) and anti‐La (SSB) antibodies, and peripheral lymphadenopathy as the first manifestation of the disease. The expression of DR3 and B8 in all three affected family members suggests familiar predisposition to SLE. The differential diagnosis and clinical course are discussed.