A comparative study of haemodynamic responses to intubation: Dexmedetomidine 1µg/kg VS Clonidine 1 µg/kg

Objectives To compare the effects of Dexmedetomidine (1µg/kg) and Clonidine (1µg/kg) on hemodynamic responses to endotracheal intubation, effect on anaesthetic requirements and effect on sedation. Material and Methods In this prospective double blind study, 60 patients scheduled for elective surgeries under general anaesthesia were randomly divided  into two groups Group D ( Inj. Dexmedetomidine dose 1μg/kg  iv) and Group C ( Inj. Clonidine dose 1μg/kg iv). Patients belonging to ASA I & ASA II of both sexes aged 20-60 years, were included in this comparative randomized study. Pulse, blood pressure, ECG were monitored continuously and  recorded before giving the study drug , after giving the study drug , at intubation then  at1,3,5,10 minutes after intubation.  Data were analysed and p 0.05)) Group C had significant rise in SBP and DBP during intubation compared to Group D. Maximum rise in SBP and DBP in Group C was 14.53% and 12.84% respectively, whereas in Group D it was 5.55% and 8.90% respectively. Dexmedetomidine group had better sedation than Clonidine group.(p<0.05) Conclusion: Dexmedetomidine significantly attenuated  the sympathetic response of laryngoscopy and  intubation as compared to Clonidine.