Helicobacter pylori eradikasyon tedavisinde 7 ve 14 günlük lansoprazol, amoksisilin, klaritromisin protokolünün karşılaştırılması

Background/aim: There is currently a debate on the duration of treatment protocols for the first-line eradication treatment of Helicobacter pylori (Hp). The aim of this study was to compare the eradication rates of 7- and 14-day treatment protocols including lansoprazole, clarithromycin, and amoxicillin in patients with nonulcer dyspepsia. Materials and methods: 188 patients (92 female, 96 male, mean age 44.8 years) with Hp-positive nonulcer dyspepsia were enrolled in the study. The presence of Hp was assessed by histological examination and urea breath test (UBT). Patients were divided into two groups randomly. The first group consisted of 96 patients given lansoprazole 30 mg bid, clarithromycin 500 mg bid, and amoxicillin 1 g bid for 14 days. The second group consisted of 92 patients given the same protocol for 7 days. Results: Six weeks after the therapy, both histological examination and UBT were repeated. If both tests were negative, it was accepted as eradication success. There were no significant differences between median ages and sex distribution of the groups (p>0.05). Eradication was achieved in 52 patients (54.2%) of the first group and in 37 patients (40.2%) of the second group. Although eradication rate was higher in the group treated for 14 days, the difference between the two groups was not statistically significant (p=0.059). Conclusion: Our study shows that neither 7- nor 14-day lansoprazole, clarithromycin, and amoxicillin protocol is significantly better in the eradication of H. pylori. In addition, since the eradication rates in both treatment protocols were lower than in previous studies, new studies are necessary to demonstrate the factors that may cause this low success rate (including antibiotic resistance); alternative therapy options are needed for H. pylori eradication.