1929 THE IMPACT OF PATHOLOGIST-DEPENDENT GLEASON SCORE VARIATIONS ON CLINICAL RISK CLASSIFICATION OF PROSTATE CANCER AFTER THE GLEASON SCORE GRADING CONSENSUS DEFINED BY THE INTERNATIONAL SOCIETY OF UROLOGICAL PATHOLOGY (ISUP: 2005)

After adjusting for the effect of other available features, the number of cores taken remained the only parameter significantly associated with the presence of pIPCa. Indeed at multivariable analyses, although the probability of having pIPCa in patients with 19 cores is not significantly higher than patients with 12 cores, patients submitted to 13-18 cores had 2.4-fold higher probability of having pIPCa compared with patients submitted to 12 cores (p 0.03). CONCLUSIONS: The number of cores taken is a major predictor of pIPCa in patients suitable for AS. In this patient group, 13-18 cores seems to be an adequate sampling to safely rely on favorable pre-operative features in addressing patients to conservative treatment. Although there are no recommendation about the sampling bioptic extent when identifying patients for AS, the number of cores taken at prostate biopsy should be carefully considered in decision making.