Successful use of a combination of two long-acting basal insulin analogs for the treatment of marked insulin resistance in type 2 diabetes unresponsive to standard therapy

Insulin resistance is a major management challenge in patients with Type 2 diabetes (T2DM). A 62-year-old female patient with T2DM caused by insulin resistance is reported. Her hyperglycemia did not respond to conventional combinations of insulin therapy. However, she responded very well to a unconventional use of the combination of two basal insulin analogs with additional short-acting insulin. This approach needs confirmation and elucidation for a potential role in these not very uncommon cases.