Elusive Conformational Dynamics of PPARγ Inactivation Tied Down by Chemical Cross-Linking

In this issue of Structure , Zheng et al. (2018) have described the dynamics of PPARγ in complex with a non-agonist by exploring its solution-phase conformational landscape through chemical cross-linking in combination with a multitude of different treatment conditions, including their new synthetic anti-diabetic non-agonist, revealing the physical mechanism of PPARγ inactivation.