Diagnosticul molecular în bolile alergice respiratorii induse de alergene perene

Molecular diagnosis is currently based on the identification, characterization and use of molecular components from complex allergenic sources. Specific features of indoor allergen exposure are due to allergic patients’ quality of life impact of perennial exposure, with frequent development of rhinitis towards asthma. In this article we present the most common sources of perennial allergens (house dust mites, furry pets and moulds), as well as their allergenic molecular components. The major allergens responsible for primary sensitization, together with possible cross-reactivity manifestations with allergenic components from animal food sources or parasites are described. Component-resolved diagnosis usefulness towards establishing an optimal approach of allergen immunotherapy, in accordance with the patient’s sensitization profile, is also addressed.