Predictive value of laboratory tests on severity of newly hospitalized patients with COVID-19

Objective: To analyze the laboratory tests in newly hospitalized patients with COVID-19 and their predictive values for the severity of the disease Methods: 83 patients, including 54 males and 29 females, with median interquartile range of 63(53-70)years diagnosed with covid-19 who were managed by Fujian medical team from January 27, 2020 to February 20, 2020 in Wuhan JinYinTan Hospital were studied retrospectively According to the severity of the disease, they were divided into common, severe and critical groups White blood cell (WBC), lymphocyte (LYM), loctate dehydrogenase (LDH), interleukin-6 (IL-6), procalcitonin (PCT), serum ferritin (SF), erythrocyte sedimentation rate (ESR), hypersensitive C-reactive protein (hs-CRP) and D-Dimer (D-D) on admission were analyzed retrospectively And the predictive value of each indicator for critical group was analyzed by Logistic regression Results: On admission, in common, severe and critical groups, WBC (×109/L) values were 7 10±3 88, 7 73±3 77 and 9 07±5 61, respectively (F = 1 315,P=0 274);IL-6 (μg/L) values were 11 76(9 42-15 18), 11 93(10 15-15 63) and 11 24(8 06-13 75), respectively(Z=0 591,P=0 744);D-D (mg/L) values were 0 70(0 48-1 12), 1 67(1 07-7 14) and 1 96(0 71-8 18), respectively(Z=3 363,P=0 186) There were no significant differences among three groups On admission, in common, severe and critical groups, LYM(×109/L) values were 1 10±0 33, 0 80±0 35 and 0 66±0 32, respectively(F=11 415,P<0 001);SF(μg/L) values were 470 83±283 43, 835 66±819 43, and 1341 15±949 54, respectively (F=7 98,P=0 001);ESR(mm/h) values were 30 76±15 70, 42 55±22 51 and 51 04±25 09, respectively(F=5 181,P=0 008);LDH(U/L) values were 314 71±105 46, 325 69±109 85 and 444 03±181 07, respectively(F=7 17,P=0 001);hs-CRP(μg/L)values were 16(7 20-19 90), 31 00(20 00-87 60) and 80 50(33 70-113 00), respectively(Z=12 185,P=0 002);PCT(μg/L) values were 0 025(0 02-0 05), 0 05(0 02-0 13) and 0 09(0 05-0 39), respectively(Z=9 694,P=0 008) There were significant differences among three groups Pairwise comparison showed that the LYM value in common group was higher than those in severe and critical groups, and the hs-CRP values in severe and critical groups were higher than that in common group,while SF, ESR, LDH and PCT values in critical group were all higher than those in severe and common groups(P<0 05) Conclusions: On admission, WBC, LYM, ESR and LDH are helpful to predict the severity of COVID-19 Although the level of IL-6 is increased, it may not be meaningful to judge the severity of COVID-19