Proximal False Lumen Thrombosis is Associated with Low False Lumen Pressure and Fewer Complications in Type B Aortic Dissection.

ABSTRACT Background Improved risk stratification is a key priority for type B aortic dissection (TBAD). Partial false lumen thrombus morphology is an emerging predictor of complications however, partial thrombosis is poorly defined and its evaluation in clinical studies is inconsistent. Purpose This work aims to characterise hemodynamic pressure in TBAD and determine how pressure relates to false lumen thrombus morphology and clinical events. Methods Retrospective admission computed tomography angiography of 69 patients with acute TBAD was used to construct three-dimensional computational models for simulation of cyclical blood flow and calculation of pressure. Patients were categorised based on false lumen thrombus morphology: minimal; proximal; distal; or extensive thrombosis. Linear regression analysis compared the luminal pressure difference between the true and false lumen for each morphology group. The impact of morphology classification on acute complications within 14 days was studied using logistic regression adjusted for clinical parameters. A survival analysis for adverse aortic events at one-year was also performed using Cox regression. Results 44 patients experienced acute complications and 45 had an adverse aortic event at one-year. Mean (±standard deviation) age was 62.6 (±12.6) years and 75.4% were male. Compared to patients with minimal thrombosis, those with proximal thrombosis had reduced false lumen pressure by 10.1mmHg (95% CI 4.3-15.9mmHg, p=.001). Individuals that did not experience an acute complication had reduced relative false lumen pressure (-6.35mmHg vs -0.62mmHg, p=.03). Proximal thrombosis was associated with fewer acute complications (OR 0.17, 95% CI 0.04-0.60 p=.01) and one-year adverse aortic events (HR 0.36, 95% CI 0.16-0.80, p=.01). Conclusions Proximal false lumen thrombosis is a marker of reduced false lumen pressure. This may explain how proximal false lumen thrombosis appears protective of acute complications (refractory hypertension or pain, aortic rupture, visceral or limb malperfusion and acute expansion) and adverse aortic events within the first year.