Cryotherapy combined with drug for endobronchial tuberculosis of granulation hyperplasia type by fiberoptic bronchoscopy

Objective To evaluate the clinical effect and security of the cryotherapy combined with drug for endobronchial tuberculosis of granulation hyperplasia type by fiberoptic bronchoscopy.Methods Forty-five patients were enrolled in this study from April 2008 to April 2010,including 19 male and 36 female.The average age was 26 years(ranged from 6 to 48 years old).All 45 patients,on the basis of the conventional antituberculosis chemotherapy,received the cryotherapy combined with drug by fiberoptic bronchoscopy once 7-14 d.Cryotherapy was performed 138 times for all patients,2.8 times per patient on average.The trachea or bronchus station,symptom such as dyspnea,hemoptysis,cough,fever were observed.Results The unblocked ratio of trachea and bronchea was 97.78%.All patients got satisfied improvement ratio of symptoms, 25/26(96.15%) for dyspnea,39/42(92.86%)for cough,24/30(80.00%)for hemoptysis and 23/25(92.00%)for fever. The Follow-up time was 6 months. There was no severe perioperative complications and mortality except for 3 cases of moderate exeduation.Conclusions The cryotherapy combined with drug for endobronchial tuberculosis of granulation hyperplasia type by fiberoptic bronchoscopy was easy to perform with minimal wound.Not only could it provide an effective and rapid control of symptoms caused by endobronchial tuberculosis of granulation hyperplasia type.it could also unobstructed bronchus promptly and improve patients quality of life.