Prophylactic and Therapeutic DNA Vaccines Against Infectious Disease

The skin is the largest as well as the most accessible organ of the human body. It has a unique population of resident antigen-presenting cells (Langerhans cells) and, in addition, a specific subset of circulating T cells homes to the skin. The skin is the target organ for most live attenuated vaccines as well as for the majority of vaccines whose immunogen is based on killed microbes, microbiological extracts or recombinant proteins.