748-P: Effects of Exercise on Continuous Glucose Monitoring Outcomes in Type 2 Diabetes: A Meta-analysis

Objective: To examine the short and long-term effects of exercise on glucose outcomes as assessed by continuous glucose monitors (CGM) in type 2 diabetes (T2D). Methods: A search of databases was performed up to May 2018. Eligible studies had participants complete standardized exercise interventions using CGM. In all short-term studies ( 8 weeks) the difference pre and post exercise training values were compared. The within participant mean differences and standard errors in 24-hour glucose concentrations between conditions was used to obtain a weighted mean difference according to the Generic Inverse Variance method (RevMan version 5.3). The I2 statistic was calculated to represent the percentage of the variability due to heterogeneity. Results: A total of 27 studies were included. Of these, 22 studies were short-term, and 5 studies were long-term interventions. Exercise decreased 24-hour glucose in short-term (-0.6 mmol/L; -0.8 to -0.4; p Conclusion: Both short and long-term exercise can lower glucose in individuals with T2D. The timing of exercise as well as non-exercise glucose values were predictors of glycemic response to short-term exercise. Disclosure M. Munan: None. C. Lemos Pinto Oliveira: None. J. Rees: None. N.G. Boule: Research Support; Self; Abbott, Medtronic.