Stability and function of regulatory T cells expressing the transcription factor T-bet

Andrew G. Levine,Alejandra Medoza,Saskia Hemmers,Bruno Moltedo,Rachel E. Niec,Michail Schizas,Beatrice Hoyos,Ekaterina V. Putintseva,Ashutosh Chaudhry,Stanislav Dikiy,Sho Fujisawa,Dmitriy M. Chudakov,Piper M. Treuting,Alexander Y. Rudensky

Stability and function of regulatory T cells expressing the transcription factor T-bet

2017

Andrew G. Levine
Alejandra Medoza
Saskia Hemmers
Bruno Moltedo
Rachel E. Niec
Michail Schizas
Beatrice Hoyos
Ekaterina V. Putintseva
Ashutosh Chaudhry
Stanislav Dikiy
Sho Fujisawa
Dmitriy M. Chudakov
Piper M. Treuting
Alexander Y. Rudensky

Regulatory T cells expressing the transcription factor T-bet selectively suppress TH1 and CD8 T cells, but not TH2 or TH17 activation and associated autoimmunity.

Keywords:

IL-2 receptor
FOXP3
Transcription factor
RAR-related orphan receptor gamma
Cytotoxic T cell
Acquired immune system
Autoimmunity
Cell biology
Immune tolerance
Biology
Immune system
GATA3

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