Multimodal assessment of normal-appearing corpus callosum is a useful marker of disability in relapsing–remitting multiple sclerosis: an MRI cluster analysis study

Background and purpose Corpus callosum (CC) is frequently involved in relapsing–remitting multiple sclerosis (RRMS). Magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) allow to study CC macrostructural and microstructural tissue integrity. Here, we applied a data-driven approach to MRI and DTI data of normal-appearing CC in RRMS subjects, and subsequently evaluated if differences in tissue integrity corresponded to different levels of physical disability and cognitive impairment.