Surface Enhanced Raman Spectroscopy and Intracellular Components

In the last decade, surface-enhanced Raman spectroscopy (SERS) met increasing interest in the detection of chemical and biological agents due to its rapid performance and ultra-sensitive features. SERS is a combination of Raman spectroscopy and nanotechnology; it includes the advantages of Raman spectroscopy, providing rapid spectra collection, small sample sizes, and characteristic spectral fingerprints for specific analytes. In this paper, we detected label-free SERS signals for arbitrarily configurations of dimers, trimers, etc., composed of gold nanoshells (AuNSs) and applied to the mapping of osteosarcoma intracellular components.