Sensitivity to cisplatin in primary cell lines derived from human glioma correlates with levels of EGR-1 expression
2011
Background
Less than 30% of malignant gliomas respond to adjuvant chemotherapy. Here, we have asked whether variations in the constitutive expression of early-growth response factor 1 (EGR-1) predicted acute cytotoxicity and clonogenic cell death in vitro, induced by six different chemotherapics.
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