Stability and functional properties of DNA-aptamers immobilized on the surface of carbon nanoparticles applicable in diagnostic and target therapy systems

The technology has been developed for the preparation of conjugates of carbon nanoparticles with DNA aptamers. The synthesis and preservation of the structural and functional properties of the resulting structures from the standpoint of their stability during long-term storage have been studied and optimised. This concerns, first of all, the prospects of using such conjugates in in vitro diagnostics and targeted therapy. Of particular importance are the data on resistance to environmental influences and attack by biologically active compounds (endonucleases). It is the activity of these molecules to nucleic acids and their fragments that constitutes the main obstacle to the use of aptamers in in vivo diagnostics and therapeutic practice. The results obtained are in favour of a real solution to existing problems.