Efficacy of Platelet-Rich Fibrin in the Treatment of Trophic Ulcer in Leprosy.

Trophic ulcer is a common disability in leprosy, recalcitrant to treatment. Platelet-rich fibrin (PRF) is a new technique for the treatment of trophic ulcer. A study was done to assess the efficacy of PRF in the treatment of trophic ulcer. Twenty-five patients of Wagner's Grade 2 trophic ulcer secondary to leprosy were enrolled. PRF was prepared and applied to ulcers and dressed; this was repeated weekly until complete healing or up to a maximum of six sittings. Ninety percent reduction in mean ulcer volume was seen at 6 weeks, with a mean healing time of 5 weeks. PRF is cost-effective, day care procedure with promising results in trophic ulcers.