In-vivo Fluorescent X-ray CT Imaging of Mouse Brain

Using a non‐radioactive iodine‐127 labeled cerebral perfusion agent (I‐127 IMP), fluorescent X‐ray computed tomography (FXCT) clearly revealed the cross‐sectional distribution of I‐127 IMP in normal mouse brain in‐vivo. Cerebral perfusion of cortex and basal ganglion was depicted with 1 mm in‐plane spatial resolution and 0.1 mm slice thickness. Degree of cerebral perfusion in basal ganglion was about 2‐fold higher than that in cortical regions. This result suggests that in‐vivo cerebral perfusion imaging is realized quantitatively by FXCT at high volumetric resolution.