The Anxiety-depressive Spectrum Disorders in the Larynx Granuloma Patients: Interdisciplinary Study

The nonspecific larynx granuloma (LG) is a nonneoplastic inflammatory nodular polipoid lesion that most often develops in the vicinity of the posterior vocal cords. The significant provocative factors include gastroesophageal reflux, intubation trauma, vocal abuse. Mental disorders (MD) in LG are not investigated still. Objective The purpose of the study was to determine the occurrence rate and the variants of MD in LG outpatients in otorhinolaryngology practice. Methods 30 LG patients (26 men and 4 women, mean age 48±8) were included to the study. MD were diagnosed in accordance with ICD-10 criteria. The severity of depression and anxiety were measured with MADRS and HAM-A. Results The MD of anxiety-depressive spectrum were diagnosed in all investigated cases: depressive episode (mild/moderate; single/recurrent (n=13;43.4%); dysthymia (n=11;36.6%); generalized anxiety disorder (n=6;20%). The LG had manifested at the background of MD in most cases (n=26;86%). The chronic stress factors had preceded MD and LG in 90% and 36.6% accordingly. The profession and anxiety related vocal abuse has been revealed in 36.6%. Conclusion The preliminary results of the interdisciplinary study have shown close relation of LG with stress related MD of anxiety-depressive spectrum.