In vitro and in vivo Characterization of a New Organic Nitrate Hybrid Drug Covalently Bound to Pioglitazone

Maike Knorr,Michael Hausding,Amanda Pfeffer,Kerstin Jurk,Thomas Jansen,Kathrin Schwierczek,Matthias Oelze,Swenja Kröller-Schön,Eberhard Schulz,Philip Wenzel,Tommaso Gori,Karl Burgin,Dirk Sartor,Armin Scherhag,Thomas Münzel,Andreas Daiber

In vitro and in vivo Characterization of a New Organic Nitrate Hybrid Drug Covalently Bound to Pioglitazone

2014

Maike Knorr
Michael Hausding
Amanda Pfeffer
Kerstin Jurk
Thomas Jansen
Kathrin Schwierczek
Matthias Oelze
Swenja Kröller-Schön
Eberhard Schulz
Philip Wenzel
Tommaso Gori
Karl Burgin
Dirk Sartor
Armin Scherhag
Thomas Münzel
Andreas Daiber

Background/Aims: Organic nitrates represent a group of nitrovasodilators that are clinically used for the treatment of ischemic heart disease. The new compound CL

Keywords:

Pioglitazone
Diabetes mellitus
Drug
In vivo
Heart disease
Nitrate
Oxidative stress
In vitro
Chemistry
Biochemistry
Covalent bond
Organic nitrates

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