NIR-Triggered Theranostic Bi2S3 Light-Transducer for On-Demand NO Release and Synergistic Gas/Photothermal Combination Therapy of Tumor

Nitric oxide (NO)-based gaseous therapy of cancer is emerged as a potential tumor therapy route. However, the development of NO generator with precisely controlled NO release in vivo is still a great challenge for gas therapy applications. Herein, a typical NO delivery platform by integrating the hollow structured polydopamine (PDA) coated Bi2S3 nanohybrids (denoted as H-Bi2S3@PDA) with a heat-sensitive S-nitrosothiols (RSNO) molecule was explored for near-infrared (NIR) light triggered on-demand NO release and synergistic gas/photothermal combination therapy of tumor. The designed H-Bi2S3@PDA nanocomposites hold high photothermal conversion efficiency of 46.13% under irradiation of NIR laser, leading to NIR light triggered controllable generation of NO gas via breaking the S-NO bonds of the heat-sensitive RSNO molecules. More importantly, synergistic gas/photothermal therapy of tumor was also achieved, which presented remarkable inhibition growth and ablation of tumor. These findings provide the opportun...