Carboxylic acid derivatives substituted fenoxicroman 6

2009 
Compound of general formula I: ** ** Formula or a salt thereof, wherein: A1 is hydrogen, CN, Cl, F, Br, OMe, (1-4C alkyl) or cyclopropyl; A2 is hydrogen, Cl, Br, F, (C1-4 alkyl) or cyclopropyl; W is -C (> = O) NR1- or -NR2C (> = O) -; R1 and R2 are each hydrogen or methyl; L is a bond, - (CR3R4) n- (CRaRb) m- (CR5R6) - *, alkenylene (C2-4), -O (C1-4 alkyl) - *, - (C1-4 alkyl) - O- *, - (C1-4 alkyl) -S - *, cycloalkylene (C3-6), or hetCyc 1, where * indicates the point of attachment to G, provided that when W is -NR2C ( > = O) -, then L is not - (CH> = CH) -; m> = 0, 1 or 2; n> = 0 or 1; Ra and Rb are independently selected from hydrogen and (C1-4 alkyl); R3 is hydrogen, (C1-4 alkyl) or CH2OH; R4 is hydrogen or methyl; R5 is hydrogen, (C1-4 alkyl), OH, -O (C1-4 alkyl) or F; R6 is hydrogen, F or methyl, or R5 and R6, together with the carbon to which they are attached form a cyclopropyl ring, hetCyc 1 is a group having the formula wherein t is 1 or 2 and p is 0 or 1, and * indicates the point of attachment to G; G is Ar1, Ar2, naphthyl, a cycloalkyl (C5-6) benzofused optionally substituted with one or more substituents independently selected from Cl and OMe, a benzo-fused heterocyclic ring members having 5-6 heteroatoms selected independently 1-2 O and N, a cycloalkyl (C3-6) alkyl optionally substituted with one or more substituents independently selected from (1-4C) alkyl, oxaespirononanilo ring, or t-butyl.
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