GTP as a biomarker of inosine monophosphate dehydrogenase (IMPDH) inhibition, in patients with advanced hematological malignancies treated with AVN944 in a phase I trial

Karina Zuck,M. J. Choe,K. J. Strand,Jeffrey Strovel,J. M. Hamilton,David K. Bol

GTP as a biomarker of inosine monophosphate dehydrogenase (IMPDH) inhibition, in patients with advanced hematological malignancies treated with AVN944 in a phase I trial

2008

Karina Zuck
M. J. Choe
K. J. Strand
Jeffrey Strovel
J. M. Hamilton
David K. Bol

14515 Background: AVN944 is an inhibitor of inosine monophosphate dehydrogenase (IMPDH), an enzyme that catalyzes the rate- limiting step in guanine nucleotide synthesis. Guanosine triphosphate (GT...

Keywords:

GTP'
IMP dehydrogenase
Biomarker (medicine)
Biochemistry
Medicine
in patient
Molecular biology
Limiting
Guanine
Guanosine triphosphate
Enzyme

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