Operating Principles of Peristaltic Pumping through a Dense Array of Valves

Immersed nonlinear elements are prevalent in biological systems that require a preferential flow direction. A certain class of models is investigated where the fluid is driven by peristaltic pumping and the nonlinear elements are ideal valves that completely suppress backflow. This highly nonlinear system produces discontinuous solutions that are difficult to study. As the density of valves increases, the pressure and flow are well-approximated by a continuum of valves which can be analytically treated. Interestingly, two different pumping mechanisms emerge from this model. At low frequencies, diffusive transport pushes open all but one valve, and the radius takes the shape of the imposed force. At high frequencies, half of the valves open, and the flow is determined by the advective transport induced by peristalsis. In either case, the induced flow is linear in the amplitude of the peristaltic forces and is independent of pumping direction. Despite the continuum approximation used, the physical valve density is accounted for by modifying the resistance of the fluid appropriately. The suppression of backflow causes a net benefit in adding valves when the valve density is low, but once the density is high enough, the dominant valve effect is to suppress the forward flow, suggesting there is an optimum number of valves per wavelength.