Improving Timely Recognition and Treatment of Sepsis in the Pediatric Intensive Care Unit

Abstract Introduction Sepsis is a leading cause of pediatric mortality worldwide. The implementation of sepsis bundles and clinical decision support tools have been useful in improving sepsis recognition and treatment. Methods Interventions targeted the pediatric intensive care unit (PICU) sepsis identification process and focused on implementation of multidisciplinary sepsis huddles prompted by an automated clinical decision support (CDS) tool. Our primary outcome measure was days between delayed sepsis recognition with secondary outcome measures of the percentage of patients receiving goal directed evidence based sepsis therapies including antibiotics within 1 hour, rapid fluid bolus within 20 minutes, and lactate measurement within 1 hour. We also tracked median time to antibiotics. Results Average days between delayed sepsis recognition improved from one episode every 9 days to one episode every 28 days. The percent of patients who received antibiotics within 1 hour improved from 33.9% to 45.5%, received a fluid bolus within 20 minutes increased from 54.7% to 61.8%, and had a lactate measured within 1 hour increased from 59.4% to 71.1% post-CDS alert; none were statistically significant. Median time to antibiotics prior to CDS alert implementation was 1.53 hours, with improvement to 1.05 hours post-implementation (p=.03). Conclusions/implications Implementation of multidisciplinary sepsis huddles and an automated CDS alert in the PICU led to an improvement in days between delayed sepsis recognition and a significant improvement in time to antibiotics.